Work

MDM4 exon skipping upon dysfunctional ribosome assembly

Year: 2024

Type: article

Abstract: Recent studies revealed how nucleolar stress enhances MDM4 exon skipping and activates p53 via the ribosomal protein L22 (RPL22; eL22). Tumor-associated L22 mutations lead to full-length MDM4 synthesis, overcoming tumor suppression by p53. This forum article explores how MDM4 splicing patterns integrate stress signaling to take p53-dependent cell fate decisions.

Source: Trends in Cell Biology

DOI: 10.1016/j.tcb.2024.10.006

Authors: Jennifer Jansen, Matthias Dobbelstein

Institutions: Universitätsmedizin Göttingen, University of Göttingen, Max Planck Institute for Multidisciplinary Sciences

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030