Exploring the Relationship Between Dietary Phytochemical Index and Chemotherapy‐Related Symptoms: Insights From a Cross‐Sectional Study
Year: 2024
Type: article
Study design: Observational Study
Abstract: ABSTRACT Phytochemicals may confer substantial benefits in alleviating chemotherapy‐related symptoms. This cross‐sectional study aimed to determine the role of dietary phytochemicals on treatment‐related symptoms in patients receiving chemotherapy. Data including demographic variables, anthropometric measures such as weight and height, 3‐day food record, and Nightingale Symptom Assessment Scale (N‐SAS), a composite measure of patients' chemotherapy‐related symptoms, were gathered via face‐to‐face interviews. The dietary phytochemical index (DPI) was computed based on the patient's food records and presented by dividing into quartiles. The study included 152 participants with a mean age of 59.59 ± 13.19 years. The mean N‐SAS score was 2.16 ± 0.80. The average DPI score for the entire group was 24.66 ± 6.55, significantly higher in women (26.61 ± 6.06) than men (23.05 ± 6.54) ( p = 0.001). As the DPI quartile values increased, there was a statistically significant decrease in N‐SAS scores ( p = 0.002). A significantly negative correlation was found between the N‐SAS score and DPI, as well as all cancers ( r = −0.364; p < 0.001). Additionally, a negative correlation was observed between the N‐SAS score and specific cancer types, comprising lung cancer ( r = −0.513; p = 0.005), breast cancer ( r = −0.612; p < 0.001), and gastrointestinal system (GIS) cancer ( r = −0.329; p = 0.033). Increasing dietary phytochemicals in chemotherapy patients may help manage treatment‐related symptoms. Phytochemicals may confer substantial benefits in alleviating chemotherapy‐related symptoms. This cross‐sectional study aimed to determine the role of dietary phytochemicals on cancer‐related symptoms in patients receiving chemotherapy. A significantly negative correlation was found between N‐SAS score and DPI and all cancers ( r = −0.364; p < 0.001) and different cancer types such as lung ( r = −0.513; p = 0.005), breast ( r = −0.612; p < 0.001), and GIS ( r = −0.329; p = 0.033). As a result, increasing dietary phytochemicals in chemotherapy patients may help manage treatment‐related symptoms.
Source: Food Science & Nutrition
DOI: 10.1002/fsn3.4568
Institutions: Yeditepe University, Istanbul Medipol University
Language: English
Topic: Cancer survivorship and care
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,460
OpenAlex ID: W4404133595