Work

Disseminated Superficial Non-actinic Porokeratosis: A Consequence of Post-traumatic Immunosuppression

Year: 2024

Type: article

Abstract: Disseminated superficial porokeratosis (DSP) is a very uncommon dermatologic condition of unknown etiology, characterized by the clonal proliferation of atypical keratinocytes associated with aberrant keratinocyte differentiation. These lead to the development of the specific cornoid lamella that separates atypical from normal keratinocytes. DSP is most frequently encountered in immunosuppressed patients. It has been described in patients receiving immunosuppressive treatments, organ transplantation and in patients diagnosed with human immunodeficiency virus, hepatitis B and hepatitis C virus infection. We present the case of a 78-year-old patient who developed disseminated non-actinic after multiple trauma and major orthopedic surgery. To our knowledge, this is the first case of DSP occurring as a consequence of post-traumatic immunosuppression reported in the medical literature. We discuss the pathogenic mechanisms, as well as the optimal diagnostic and therapeutic approach in such cases.

Source: Cureus

DOI: 10.7759/cureus.73218

Authors: Liliana G Popa, Teodora Cristiana Gradinaru, Calin Giurcaneanu, Irina Tudose, Cristina Iolanda Vivisenco, Cristina Beiu

Institutions: Carol Davila University of Medicine and Pharmacy, Bucharest Emergency University Hospital, Spitalul Universitar de Urgență Elias, Clinical Emergency Hospital Bucharest

Language: English

Topic: Genetic and rare skin diseases.

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4404136688