“If you build it, they will come”: the convergence of funding, research and collaboration in paediatric brain cancer clinical trials
Year: 2024
Type: article
Abstract: Each year, approximately 1000 children in Australia and New Zealand, aged 0–14 years, are diagnosed with cancer. Despite paediatric cancer accounting for less than 1% of all cancer cases, the impact on their families and communities is profound and disproportionate.1-3 Paediatric brain cancers are the most significant cause of cancer-related deaths within this age group, responsible for 40% of fatalities despite representing only 14% of diagnoses.2 Although significant advances in paediatric cancer treatments have pushed overall cure rates above 80%, the outlook for many brain tumour types remains bleak.4 Moreover, survivors often face lifelong clinical sequelae that severely diminish their quality of life,5 with 60% of survivors unable to reach independence in adulthood.6 This stark reality underscores the need for the expansion of clinical trials and integrated preclinical research aimed at improving outcomes for these individuals.
Source: The Medical Journal of Australia
DOI: 10.5694/mja2.52506
Authors: Jordan Hansford, Santosh Valvi, Jasper de Boer, Geoff McCowage, Dinisha Govender, Maria Kirby, David Ziegler, Neevika Manoharan, Timothy Hassall, Brandon Wainwright, Frank Alvaro, Paul J Wood, David Eisenstat, Dong Anh Khuong Quang, Misty Jenkins, Matthew Dun, Stephen J Laughton, Raelene Endersby, Andrew Dodgshun, Nicholas Gottardo
Institutions: Women's and Children's Hospital, South Australian Health and Medical Research Institute, The Kids Research Institute Australia, Princess Margaret Hospital for Children, Perth Children's Hospital, Hudson Institute of Medical Research, ANZCHOG, Children's Hospital at Westmead, Sydney Children's Hospital, The University of Queensland, Children's Health Queensland Hospital and Health Service, Hunter Medical Research Institute, John Hunter Children's Hospital, University of Newcastle Australia, Monash Children’s Hospital, Monash Health, Monash University, Royal Children's Hospital, Walter and Eliza Hall Institute of Medical Research, Starship Children's Health, The University of Western Australia, Christchurch Hospital
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,240
OpenAlex ID: W4404141338