Year: 2024
Type: article
Study design: Observational Study
Abstract: Pseudomonas aeruginosa (Pa) and Methicillin susceptible Staphylococcus aureus (MSSA) are the predominant bacteria found in the airways of people with cystic fibrosis (pwCF), significantly contributing to lung disease progression. While various factors influencing the initial acquisition (IA) of these pathogens are known, the impact of environmental conditions remains understudied. This epidemiological study assessed the risk of MSSA and Pa initial acquisitions in relation to seasonality and climatic zones among 1,184 French pwCF under 18 years old. The age at IA for Pa (Pa-IA) and MSSA (MSSA-IA) was estimated using the Kaplan-Meier method. Seasonality and climatic zones were analysed as risk factors using time-varying Cox regression models. The median age at MSSA-IA was notably earlier (2.0 years) than that at Pa-IA (5.1 years). MSSA-IA occurred increasingly younger in more recent birth cohorts, while the age at Pa-IA remained stable over time. The risk of Pa-IA was consistently higher in all seasons compared with spring, peaking in autumn (HR = 1.53), irrespective of climatic zones. In Oceanic and Continental climates, the highest risk for MSSA-IA was in winter (HRs = 1.45 and 1.20 respectively). In the Mediterranean climate, the risk of MSSA-IA was lower in winter compared to spring (HRs = 0.68 and 0.61 respectively), and the median age at MSSA-IA later than for Pa-IA. This study demonstrates that seasonality and meteorological factors may influence acquisition of MSSA and Pa in pwCF. These findings suggest that environmental factors play a role in pathogen acquisition dynamics in CF and could inform the development of preventive strategies.
Source: Scientific Reports
Authors: Julie Mésinèle, Manon Ruffin, Loïc Guillot, Pierre-Yves Boëlle, Harriet Corvol, French CF Modifier Gene Study Investigators, Michel Abelly, Nathalie Allou, Baptiste Arnouat, Carole Bailly Piccini, Chantal Belleguic, Katia Bessaci, Tiphaine Bihouee, Yves Billon, François Bremont, Jacques Brouard, Stéphanie Bui, Pierre-Régis Burgel, Boubou Camara, Karine Campbell, Raphael Chiron, Emmanuelle Coirier-Duet, Harriet Corvol, Laure Cosson, Marie-Laure Dalphin, Isabelle Danner-Boucher, Valérie David, Éric Deneuville, Philippe Domblides, Stéphane Dominique, Jean-Christophe Dubus, Nadine Dufeu, Isabelle Durieu, Sandra Dury, Ralph Epaud, Annlyse Fanton, Michael Fayon, Pierre Foucaud, Michèle Gerardin, Jean-Louis Ginies, Dominique Grenet, Marie-Christine Heraud, Véronique Houdouin, Dominique Hubert, Frédéric Huet, Romain Kessler, Alice Ladaurade, Jeannes Languepin, Muriel Laurans, Pascal Le Roux, Olivier Le Rouzic, Sylvie Leroy, Cathie Llerena, Julie Macey, Julie Mankikian, Christophe Marguet, Laurent Mely, Marie Mittaine, Anne Munck, Marlène Murris-Espin, Nadia Nathan, Raphaëlle Nove-Josserand, Caroline Perisson, Isabelle Pin, Sophie Ramel, Cinthia Rames, Gilles Rault, Philippe Reix, Natacha Remus, Martine Reynaud-Gaubert, Bénédicte Richaud-Thiriez, Manuëla Scalbert-Dujardin, Isabelle Sermet-Gaudelus, Nathalie Stremler, Véronique Storni, Aurélie Tatopoulos, Guillaume Thouvenin, Françoise Troussier, Philippe Vigneron, Laurence Weiss, Nathalie Wizla
Institutions: Inserm, Sorbonne Université, Centre de Recherche Saint-Antoine, Inovarion (France), Assistance Publique – Hôpitaux de Paris, Hôpital Saint-Antoine, Institut Pierre Louis d‘Épidémiologie et de Santé Publique, Hôpital Armand-Trousseau, Centre Hospitalier Universitaire de Reims, Centre hospitalier Bretagne Atlantique, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Rennes, Centre Hospitalier Universitaire de Nantes, Nantes Université, Centre Hospitalier Régional et Universitaire de Nancy, Centre Hospitalier Universitaire de Toulouse, Centre Hospitalier Universitaire de Caen Normandie, Centre Hospitalier Universitaire de Bordeaux, Centre Hospitalier Universitaire de Grenoble, Hôpital Arnaud de Villeneuve, Hôpital André Mignot, Centre Hospitalier Universitaire de Tours, Centre Hospitalier Universitaire de Besançon, Centre Hospitalier Universitaire de Rouen, Assistance Publique Hôpitaux de Marseille, Hôpital de la Timone, Hôpital Nord, Hospices Civils de Lyon, Hôpital Intercommunal de Créteil, CHU Dijon Bourgogne, Centre Hospitalier Universitaire d'Angers, Hôpital Foch, Hôpitaux Universitaires de Strasbourg, Centre Hospitalier Universitaire de Limoges, Centre Hospitalier Universitaire de Lille, Hôpital Femme Mère Enfant, Centre Hospitalier de Bretagne Sud
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,590
OpenAlex ID: W4404147420