Physical activity and DNA methylation–based markers of ageing in 6208 middle-aged and older Australians: cross-sectional and longitudinal analyses
Year: 2024
Type: article
Study design: Observational Study
Abstract: Epigenetic age quantifies biological age using DNA methylation information and is a potential pathway by which physical activity benefits general health. We aimed to assess the cross-sectional and longitudinal associations between physical activity and epigenetic age in middle-aged and older Australians. Blood DNA methylation data for 6208 participants (40% female) in the Melbourne Collaborative Cohort Study (MCCS) were available at baseline (1990–1994, mean age, 59 years) and, of those, for 1009 at follow-up (2003–2007, mean age, 69 years). Physical activity measurements (weighted scores at baseline and follow-up and total MET hours per week at follow-up) were calculated from self-reported questionnaire data. Five blood methylation–based markers of ageing ( PCGrimAge , PCPhenoAge , bAge , DNAmFitAge , and DunedinPACE ) and four fitness-related markers ( DNAmGaitspeed , DNAmGripmax , DNAmVO2max , and DNAmFEV1 ) were calculated and adjusted for age. Linear regression was used to examine the cross-sectional and longitudinal associations between physical activity and epigenetic age. Effect modification by age, sex, and BMI was assessed. At baseline, a standard deviation (SD) increment in physical activity was associated with 0.03-SD ( DNAmFitAge , 95%CI = 0.01, 0.06, P = 0.02) to 0.07-SD ( bAge , 95%CI = 0.04, 0.09, P = 2 × 10 −8 ) lower epigenetic age. These associations were attenuated after adjustment for other lifestyle variables. Only weak evidence was found for the longitudinal association ( N = 1009) of changes in physical activity and epigenetic age (e.g. DNAmFitAge : adjusted β = − 0.04, 95%CI = − 0.08, 0.01). The associations were not modified by age, sex, or BMI. In middle-aged and older Australians, higher levels of self-reported physical activity were associated with slightly lower epigenetic age.
Source: GeroScience
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,190
Awards: Methylation of DNA and colorectal cancer, Methylation as a risk and prognostic factor for breast cancer, Delivering Precision Medicine to Population-based Cancer Prevention, Methylation and the risk of urothelial cell cancer, LIFEPATH: life-course biological pathways underlying social differences in healthy ageing, A prospective study of the influence of health-related lifestyle factors on DNA methylation, Precision Public Health for major cancers - novel approaches to building the genetic, epigenetic and lifestyle knowledge base for assessing risk and prognosis, Methylation as a risk factor for prostate cancer., Novel molecular markers of lung cancer risk and survival
OpenAlex ID: W4404147674