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One-Step Palladium-Catalyzed Heterocyclic Ring Closure of Benzofurans with Aryl Iodides through a Heck-Type Pathway

Year: 2024

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide An operationally simple and robust method for the direct arylation and ring closure of benzofurans is reported. Besides the mild conditions and good reaction yields, the methodology is applicable for a wide range of derivatives using commercially available aryl iodides with complete C 2 regioselectivity. The reaction is proposed to follow a Heck-type oxyarylation mechanism. The facile synthesis method will enable the development of new materials for diverse applications in biology and catalysis and as precursors for organic semiconductors.

Source: Organic Letters

DOI: 10.1021/acs.orglett.4c03602

Authors: Fathy Hassan, Nivedha Velmurugan, Yusuke Yamane, Síle Nic Chormaic, Christine K. Luscombe

Institutions: Okinawa Institute of Science and Technology Graduate University, Tanta University, Keio University

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Keio University, Okinawa Institute of Science and Technology Graduate University, Tanta University, Japan Society for the Promotion of Science