Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex
Year: 2024
Type: article
Abstract: Electroacupuncture (EA) has been successfully used to treat painful conditions. However, its analgesic mechanism remains poorly understood. Here, we established a Complete Freund's Adjuvant (CFA)-induced inflammatory pain model. After CFA injection, P2RY14 was upregulated in primary somatosensory cortex of hindlimb (S1HL). EA, not sham EA, alleviated the nociceptive thermal hyperalgesia and reduced the upregulation of P2RY14 of CFA mice. Injection of P2RY14 agonist uridine diphosphate glucose (UDPG) into bilateral S1HL reversed EA-induced analgesia. Our results demonstrate that EA-induced analgesia of CFA-induced pain can be achieved by downregulation of P2RY14 in the S1HL.
Source: Purinergic Signalling
Authors: Shuai Hou, Cui-Yuan Chen, Rui-Zhu Zhou, Liu-Xuan He, Xiao-Xiao Zhao, Sha-Sha Chen, Sha Yang, Hai-Yan Yin, Shu-Guang Yu
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,390
Awards: G3582686020, G7305570880
OpenAlex ID: W4404148442