Year: 2024
Type: article
Study design: Observational Study
Abstract: Purpose [18F]AlF-NOTA-FAPI-04 demonstrates significant physiological uptake in the gallbladder and biliary tract system, representing a limitation of this positron emission tomography (PET) tracer. The aim of this study was to evaluate the impact of milk consumed prior to a PET/CT scan on [18F]AlF-NOTA-FAPI-04 uptake in normal abdominal organs. Materials and methods A total of 86 patients who underwent [18F]AlF-NOTA-FAPI-04 PET/CT imaging took part in this single-center retrospective clinical study at the Hunan Cancer Hospital between December 2020 and August 2021. Patients were divided into two groups according to their pre-PET scan diet: treated group, who consumed 250 mL of milk 10 ± 5 min after the tracer injection, while the control group was permitted no food intake subsequent to the radiotracer administration. The mean standardized uptake value (SUVmean) of gallbladder, liver, small intestine and pancreas were measured in 18F-FAPI and 18F-FDG PET/CT. Results There was a statistically significant difference in the 18F-FAPI uptake in the gallbladder between the treated group and the control group (p < 0.001). The average SUVmean in the treated group was 2.19 ± 2.01, which was significantly lower than the average SUVmean of 10.04 ± 9.66 in the control group. In the subgroup analysis of patients who underwent paired [18F]FDG and [18F]FAPI PET/CT scans, the 18F-FAPI uptake of liver and small intestine was significantly lower than the 18F-FDG uptake in both the treated group and the control group (p < 0.001). Conclusion This study suggests that milk consumption decreases physiological 18F-FAPI uptake in the gallbladder, potentially enhancing the diagnostic accuracy for gallbladder cancer.
Source: Frontiers in Medicine
Institutions: Central South University, Hunan Cancer Hospital
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,295
OpenAlex ID: W4404159958