Year: 2024
Type: article
Abstract: BACKGROUND/AIMS: In today's age, celiac disease (CD) is no longer solely characterized by chronic diarrhea in a malnourished child. Obesity is gradually being acknowledged as part of CD's clinical course. Both conditions have been linked to alterations of gut microbiome. Given the difficulty of strict gluten-free diet adherence, there is a need for less restrictive adjunctive therapies. We aimed to investigate the prevalence of obesity in patients diagnosed with CD with the goal of developing new therapeutic approaches. METHODS: Baseline data from the National Institute of Health's All of Us Research Program, was used to evaluate the relationship between CD and obesity. A retrospective cohort study was conducted where groups of individuals with CD and without CD were matched by age range and health surveys. Statistical analysis with odds ratios (OR) with 95% confidence intervals (CI) were reported. RESULTS: The prevalence of obesity was 32.6% in the CD group compared to 18.4% in the control group (OR, 2.111; 95% CI, 1.914-2.328; P< 0.0001). Women accounted for a greater population of patients with CD and obesity. The largest percentage of patients with CD and obesity were older than 65 years. The highest percentage of individuals in both the experimental and control groups were white, followed by African Americans. CONCLUSIONS: Our data shows a significant association between CD and increased prevalence of obesity. These results warrant further investigation into microbial changes and dietary exposures that affect the pathogenesis of both diseases.
Source: Intestinal Research
Institution: Nova Southeastern University
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: National Institutes of Health
Awards: Healthy Americas: All of Us Research Program, University of Arizona-Banner Health All of Us Research Program , SouthEast Enrollment Center (SEEC) , G9000004253, G9000006085, G9000011423, G9000013175, G9000021463, G9000021538, G9000035207, G9000051044, G9000055272, G9000063695, G9000063797, G9000077829, G9000085573, G9000128449, G9000290334, G9000303384
OpenAlex ID: W4404160809