Work

[miR-2110 Affects the Biological Behaviors of Lung Adenocarcinoma by Regulating CDT1].

Year: 2024

Type: other

Abstract: Objective: To investigate the effect of miR-2110 on the biological behaviors, such as cell proliferation, apoptosis, and metastasis, of lung adenocarcinoma (LUAD) cells by means of cell and animal experiments. Methods: experiments. Results: experiments showed that miR-2110 overexpression significantly decreased the expression of Ki67, a tumor proliferation index, and vimentin and MMP9, two metastasis indices, compared with the control group. Conclusion: miR-2110 can inhibit proliferation and metastasis of LUAD by targeting CDT1, providing a new rationale for the treatment of LUAD.

Source: PubMed

DOI: 10.12182/20240960505

Authors: Yuan Mi, Xuzhe Li, Cong Wang, Chenxi Lin, Zhichao Zhao, Xiaofei Yan, Ping Shi, Lei Wang

Institutions: Hebei Medical University, Fourth Hospital of Hebei Medical University

Language: Chinese

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4404162840

Cites: 19

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Related to: 10