Work

[Overwork induces vascular endothelial barrier dysfunction in mice].

Year: 2024

Type: other

Abstract: OBJECTIVE: To investigate the impact of overwork on vascular endothelial barrier function in mice. METHODS: ; immunofluorescence assay was used to detect the protein expressions of claudin-5, ZO-1, VE-cadherin, and Syndecan-1. RESULTS: < 0.05). The protein expressions of claudin-5, ZO-1, VE-cadherin, and Syndecan-1 were all significantly reduced in W4 group. CONCLUSION: Prolonged overwork can cause damage of the intercellular junction complexes in arterial endothelial cells and the endothelial glycocalyx to result in impaired barrier function and increased vascular permeability in mice.

Source: PubMed

DOI: 10.12122/j.issn.1673-4254.2024.09.22

Authors: Y Liao, X Ma, S Deng, S Chen, Y Li

Institution: First Hospital of Lanzhou University

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4404162900

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