[Experimental Study on Biomimetic Curcumin-Mediated Sonodynamic Therapy of Melanoma].
Year: 2024
Type: other
Abstract: Objective: To study the role of curcumin-mediated sonodynamic therapy in the treatment of malignant melanoma, and to provide a new strategy for the treatment of malignant melanoma. Methods: anti-melanoma therapeutic effect of ultrasound combined with biomimetic curcumin. Results: <0.05). HE staining showed no obvious abnormalities in the morphology of heart, liver, spleen, lung, and kidney tissues in any of the treatment groups. HE staining showed the most significant changes in cell morphology in the biomimetic curcumin and ultrasound combination group, followed by the biomimetic curcumin group and the curcumin group. No obvious abnormalities in tumor cell morphology were observed in the ultrasound group. According to the respective results of CD31 staining, Ki67 staining, and TUNEL staining, the biomimetic curcumin and ultrasound combination group had the largest brown area, the highest number of red fluorescence, and the highest number of green fluorescence, followed by the biomimetic curcumin group and the curcumin group. Conclusion: .
Source: PubMed
DOI: 10.12182/20240960108
Authors: Xiao Rong, Xi Xiang, Yicheng Zhao, Li Qiu, Fangxue DU
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4404162903