Ambient PMs pollution, blood pressure, potential mediation by short-chain fatty acids: A prospective panel study of young adults in China
Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The concurrent effects of particulate matter (PM) on both blood pressure (BP) and short-chain fatty acids (SCFAs) are insufficiently explored, with limited research on the potential mediating roles of SCFAs. METHODS: )) on BP and SCFAs, along with potential mechanisms. Real-time PM data, urinary SCFAs levels, and BP indicators were systematically collected. Linear mixed-effects models assessed the relationships between PM, SCFAs, and BP. Mediation analyses explored SCFAs' mediating role in the PM-BP association. RESULTS: . Stronger associations were found in females and individuals with abnormal BMI. CONCLUSIONS: Our study shows that PM exposure decreases urinary SCFAs levels, which partially mediate the impact of PM on elevated BP. These findings enhance our comprehension of the pathways linking PM exposure to BP changes.
Authors: Xin Chou, Miao Fang, Yue Shen, Cunzhong Jiang, Lin Miao, Liyan Yang, Zexi Wu, Xiangyu Yao, Kunpeng Ma, Kun Qiao, Zhijing Lin
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,990
Awards: G2131696335, G4131763613, G675662579
OpenAlex ID: W4404163725