Work

Catalytic Aldehyde–Alkyne Couplings Triggered by Ketyl Radicals

Year: 2024

Type: article

Abstract: A general and flexible platform for catalytic aldehyde-alkyne couplings triggered by ketyl radicals is described. This open-shell strategy necessitates only a catalytic quantity of a photoredox catalyst, along with Hünig's base (DIPEA) as a halogen atom transfer reagent. The reaction proceeds through sequential steps involving activation, halogen atom transfer, and radical addition. This carbonyl-alkyne coupling exhibits a wide substrate scope and functional group compatibility and has been successfully applied to the late-stage modification of complex architectures.

Source: Organic Letters

DOI: 10.1021/acs.orglett.4c03802

Authors: Zhi-Xi Xing, Shu-Sheng Chen, Huan-Ming Huang

Institution: ShanghaiTech University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: National Natural Science Foundation of China, ShanghaiTech University