Work

Podophyllotoxin and Aryltetralin Lignans: Methods for the Synthesis of Rings A, B, C, D

Year: 2024

Type: article

Abstract: Podophyllotoxin, its derivatives and structural analogues are an extensive group of aryl-tetralin-lignans of interest in pharmacology due to their promising anticancer and antitumor activity. The synthesis methods that have been proposed to date seek to resolve synthetic, stereochemical, pharmacodynamic and environmental aspects. In this review we have updated and brought together different classifications of lignan and podophyllotoxin synthesis. Transformation methods focus on the strategies used to form or functionalize rings A, B, C and D, as well as the configuration of the system of four stereogenic centers that fuse rings C and D.

Source: Journal of organic and pharmaceutical chemistry

DOI: 10.24959/ophcj.24.308942

Authors: Francisco Flores-Hernández, Tania Isabel Zárate-López, Marco Antonio Alcaráz-Cano, Jaime Escalante, José Domingo Rivera-Ramírez

Institutions: Universidad de Guadalajara, Universidad Autónoma del Estado de Morelos

Language: English

Topic: Plant-derived Lignans Synthesis and Bioactivity

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

OpenAlex ID: W4404184638

FWCI: 0.118

Cites: 86

Cited by: 1

Related to: 10