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Diastereoselective Anomeric C(sp 3 )−H Cyclization Towards the Design of New Cyclophane‐Braced Glycopeptides

Year: 2024

Type: article

Abstract: Here we report a macrocyclization route towards the synthesis of glycophane peptides by a selective C−H arylation of the anomeric bond. This approach demonstrates the power of Pd‐catalysis C−H activation to access unusual cyclic peptides.

Source: Angewandte Chemie

DOI: 10.1002/ange.202418057

Authors: Sakna Bazzi, Ameni Hadj Mohamed, Dmytro Ryzhakov, Juba Ghouilem, Mehdi A. Beniddir, Vincent Gandon, Samir Messaoudi

Institutions: Centre National de la Recherche Scientifique, Université Paris-Saclay, Biomolécules : Conception, Isolement, Synthèse, École Polytechnique, École Nationale Supérieure de Techniques Avancées, Laboratoire de Synthèse Organique, Institut de Chimie Moléculaire et des Matériaux d'Orsay

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $5,250

OpenAlex ID: W4404187781

FWCI: 0.282

Cites: 68

Cited by: 2

Related to: 10