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NETosis Is an Important Component of Chronic Myocardial Inflammation in Patients With Heart Failure

Year: 2024

Type: article

Abstract: cardiomyopathy; coronary artery disease; extracellular traps; heart failure; myocarditis; neutrophils Low-grade myocardial inflammation is an important factor in the development and progression of heart failure (HF). 1 Polymorphonuclear neutrophils are powerful triggers of inflammation as they form neutrophil extracellular traps (NETs), which are associated with neutrophil death, known as NETosis. 2 NE (neutrophil elastase), MPO (myeloperoxidase), PAD4 (peptidylarginine deiminase-4), and citH3 (citrullinated histone-3) are not only the mechanisms but also the markers of NETosis.2,

Source: Circulation Heart Failure

DOI: 10.1161/circheartfailure.124.012231

Authors: Sawa Kostin, Manfred Richter, Florian Krizanic, Benjamin Sasko, Theodoros Kelesidis, Nikolaos Pagonas