Association of amyloid and cardiovascular risk with cognition: Findings from KBASE
Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Limited research has explored the effect of cardiovascular risk and amyloid interplay on cognitive decline in East Asians. METHODS: Vascular burden was quantified using Framingham's General Cardiovascular Risk Score (FRS) in 526 Korean Brain Aging Study (KBASE) participants. Cognitive differences in groups stratified by FRS and amyloid positivity were assessed at baseline and longitudinally. RESULTS: Baseline analyses revealed that amyloid-negative (Aβ-) cognitively normal (CN) individuals with high FRS had lower cognition compared to Aβ- CN individuals with low FRS (p < 0.0001). Longitudinally, amyloid pathology predominantly drove cognitive decline, while FRS alone had negligible effects on cognition in CN and mild cognitive impairment (MCI) groups. CONCLUSION: Our findings indicate that managing vascular risk may be crucial in preserving cognition in Aβ- individuals early on and before the clinical manifestation of dementia. Within the CN and MCI groups, irrespective of FRS status, amyloid-positive individuals had worse cognitive performance than Aβ- individuals. HIGHLIGHTS: Vascular risk significantly affects cognition in amyloid-negative older Koreans. Amyloid-negative CN older adults with high vascular risk had lower baseline cognition. Amyloid pathology drives cognitive decline in CN and MCI, regardless of vascular risk. The study underscores the impact of vascular health on the AD disease spectrum.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.14290
Authors: Soumilee Chaudhuri, Desarae A. Dempsey, Yen‐Ning Huang, Tamina Park, Sha Cao, Evgeny J. Chumin, Hannah Craft, Paul K. Crane, Shubhabrata Mukherjee, Seo‐Eun Choi, Phoebe Scollard, Michael Lee, Connie Nakano, Jesse Mez, Emily H. Trittschuh, Brandon S. Klinedinst, Timothy J. Hohman, Jun‐Young Lee, Koung Mi Kang, Chul‐Ho Sohn, Yu Kyeong Kim, Dahyun Yi, Min Soo Byun, Shannon L. Risacher, Kwangsik Nho, Andrew J. Saykin, Dong Young Lee
Institutions: Indiana University Indianapolis, Indiana University School of Medicine, Indiana University – Purdue University Indianapolis, University of Washington, Boston University, VA Puget Sound Health Care System, Harborview Medical Center, Vanderbilt University Medical Center, SNUH SMG-SNU Boramae Medical Center, Seoul National University Hospital, Seoul National University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,000
Awards: G1024368718, G1041081925, G107491585, G1171648585, Indiana Alzheimer Disease Center, G1576357080, G2562979282, G2619161350, G2815983834, G2957681590, G29951154, G3146424788, G365537114, G3881770169, G4079001475, G4350118794, G5090083847, G607802463, G6092455194, G6245148141, G9000011165, G9000011920, G9000020039, G9000033611, G9000055340, G9000056510, G9000062785, G9000068750, G9000122335, G9000162324, Social Networks in Alzheimer Disease 2.0., KBASE2: Korean Brain Aging Study, Longitudinal Endophenotypes and Systems Biology, Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease Biobanks
OpenAlex ID: W4404195900