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Refractory Immune Thrombocytopenia With Antiphospholipid Antibodies

Year: 2024

Type: article

Abstract: This case report details a 28-year-old female with refractory immune thrombocytopenia (ITP) and antiphospholipid antibodies (aPL). Initial management with corticosteroids, IVIG(intravenous immunoglobulin), and thrombopoietin receptor agonists (TPO-RAs) failed to sustain adequate platelet counts. The patient later suffered a subarachnoid haemorrhage and suspected adrenal thrombosis, complicating her condition.This report highlights the challenges of managing refractory ITP with aPL, emphasizing the need for individualized therapeutic strategies and vigilant monitoring to balance thrombosis and bleeding risks. Long-term immunosuppression with azathioprine stabilized her platelet count,providing a viable management approach for similar complex cases.

Source: PARIPEX-INDIAN JOURNAL OF RESEARCH

DOI: 10.36106/paripex/5808578

Authors: Praneeth Gorantla, Vaishnavi S, R B Sudagar Singh

Institution: Sri Ramachandra Institute of Higher Education and Research

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4404206590

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