Year: 2024
Type: article
Study design: Observational Study
Abstract: Background Both depression and respiratory disease are common today in young populations. However, little is known about the relationship between them. Aims This study aims to explore the association between depression in childhood to early adulthood and respiratory health outcomes in early adulthood, and the potential underlying mechanisms. Method A prospective study was conducted based on the Swedish BAMSE (Barn, Allergi, Miljö, Stockholm, Epidemiologi [Children, Allergy, Milieu, Stockholm, Epidemiology]) birth cohort (n = 4089). We identified clinically diagnosed depression through the dispensation of antidepressants, using national register data confirmed by self-reported diagnosis. At the 24-year follow-up, respiratory health was assessed via questionnaires and clinical evaluation. Metabolic and inflammatory profiles were analysed to explore potential mechanisms. Results Among the 2994 participants who provided study data, 403 (13.5%) had depression at any time point from around age 10 to 25 years. Depression was associated with higher risks of any chronic bronchitis symptoms (odds ratio = 1.58, 95% CI 1.21–2.06) and respiratory symptoms (odds ratio = 1.41, 95% CI 1.11–1.80) in early adulthood, independent of body mass index (BMI) and smoking status. Compared to individuals without depression, those with depression had a higher fat mass index (FMI (β = 0.48, 95% CI 0.22–0.74)) and increased blood levels of fibroblast growth factor 21 and Interleukin-6 in early adulthood. These markers together with FMI were found to partly mediate the association between depression and respiratory symptoms (total mediation proportion: 19.8 and 15.4%, respectively, P < 0.01). Conclusions Depression in childhood to early adulthood was associated with an increased risk of respiratory ill-health in early adulthood, independently of smoking. Metabolic and inflammatory dysregulations may underlie this link.
Source: BJPsych Open
DOI: 10.1192/bjo.2024.794
Institutions: Sichuan University, West China Medical Center of Sichuan University, Karolinska Institutet, West China Hospital of Sichuan University, Stockholm South General Hospital, Sachs' Children and Youth Hospital, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Uppsala University, UNSW Sydney, Centre for Big Data Research in Health, Karolinska University Hospital, Region Stockholm
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,450
Awards: G2891770485, G360110518, Premenstrual disorders: the key to addressing sex disparities in mental health among adolescents and young adults, G4337010896, Exposure to air pollution and respiratory health from childhood to adulthood, G5783672432, G6478037549, From fetal life to early adulthood: tobacco exposure, diet and health, G712881263, Indoor environment and respiratory health – a longitudinal study from childhood to early adulthood, Justifying hard decisions - a necessary evil in representative decision making, Genetic and early-life determinants of premenstrual disorders, G8866978948
OpenAlex ID: W4404221315