Work

Factors associated with time to relapse in pulmonary tuberculosis patients using penalized Cox models

Year: 2024

Type: article

Abstract: BACKGROUND: Pulmonary tuberculosis (TB) is a contagious bacterial infection caused by Mycobacterium tuberculosis that primarily affects the lungs. Despite advances in treatment, TB remains a major public health challenge, particularly in developing countries. This retrospective cohort study aimed to identify factors that influence the time to relapse in patients with pulmonary tuberculosis. METHODS: All smear-positive pulmonary tuberculosis patients (1548 patients) whose data were recorded in the tuberculosis registration system of Golestan University of Medical Sciences and Health Services from March 2014 to March 2019, and followed up until February 2021. To analyze the data, we applied LASSO, MCP, and SCAD penalized Cox models. RESULTS: 35, HR = 2.77), marital status (married vs. single, HR = 8.49), chronic renal failure (Yes vs. No, HR = 5.36), and pre-treatment smear test results (+ 1 vs. 1-9Basil, HR = 0.65 and + 2 vs. 1-9Basil, HR = 0.96) influenced time to relapse according to the MCP penalized Cox regression model. CONCLUSIONS: Health care systems should focus on identification of factors that influence time to relapse and developing interventions to reduce relapse rates.

Source: BMC Research Notes

DOI: 10.1186/s13104-024-06986-3

Authors: Zahra Mehrbakhsh, Ghodratollah Roshanaei, Nasser Behnampour, Leili Tapak

Institutions: Hamedan University of Medical Sciences, Golestan University of Medical Sciences

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,790