Anti‐ MDA5 positivity: describing the frequency and spectrum of clinically evident MDA5 disease
Year: 2024
Type: article
Study design: Observational Study
Abstract: To evaluate experience in a tertiary rheumatology service with melanoma differentiation-association-protein-5 (MDA5) disease and testing, patients with positive autoantibody results were reviewed for the presence of clinical disease. Anti-MDA5 positivity was detected in 2% of myositis-specific antibody tests. Of these, 29% did not have features consistent with anti-MDA5 disease. However, when present, MDA5 disease is severe with a high mortality.
Source: Internal Medicine Journal
DOI: 10.1111/imj.16563
Authors: Janelle See, Jessica L. Fairley, Ai L. Yeo, Samar Ojaimi, Eric F. Morand
Institutions: Monash Health, The University of Melbourne, Monash University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4404226371