Work

Closing the Loop: Low‐Waste Phosphorus Functionalization Enabled by Simple Disulfides

Year: 2024

Type: article

Abstract: Useful monophosphorus products are obtained from both white and red phosphorus via a simple strategy involving initial oxidation by aryl disulfides followed by quenching with nucleophiles. Direct transformations of elemental phosphorus are usually very challenging, forcing chemists to instead rely on inefficient and hazardous multi-step methods. However, here they are achieved using inexpensive and easy-to-handle reagents, providing access to diverse P-C, P-N and P-O bonded products in good yields. By isolating the thiolate byproducts of these reactions, a simple, closed loop can be achieved that produces only minimal, benign waste byproducts, in contrast to other direct methods. This closed loop can even be elaborated into a true (electro)catalytic cycle, which is extremely rare in the field of elemental phosphorus functionalization.

Source: ChemSusChem

DOI: 10.1002/cssc.202401895

Authors: Thomas M. Horsley Downie, Ajdin Velić, Luis A. Coelho, Robert Wolf, Daniel J. Scott

Institutions: University of Strathclyde, University of Regensburg, University of Bath

Language: English

Topic: Organophosphorus compounds synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: hybrid

Estimated APC paid: $4,330