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Concurrent Guillain–Barre/acute transverse myelitis overlap syndrome after COVID-19 infection in a patient with ITP: A case report

Year: 2024

Type: article

Abstract: RATIONALE: Patients with chronic immune diseases, such as idiopathic thrombocytopenic purpura (ITP), should be alert for Guillain-Barre/acute transverse myelitis (GBS/ATM) overlap syndrome after infection with coronavirus disease 2019 (COVID-19). PATIENT CONCERNS: A 65-year-old male with an ITP history, who presented with limb numbness and weakness, urinary retention, right peripheral facial paralysis, and diplopia 2 weeks after being diagnosed with COVID-19. DIAGNOSIS: GBS/ATM overlap syndrome secondary to COVID-19. INTERVENTIONS: Five days intravenous immune globulin, methylprednisolone (500 mg) was added for treatment. He was discharged with medicine and continued to take Methylprednisolone tablets (60 mg/d), Eltrombopag olamine (25 mg 1/d), Mecobalamine tablets, vitamin B1, and rehabilitation treatment outside the hospital. OUTCOMES: The patient significantly improved after initial treatment, he returned to normal life after 8 weeks. Five months later, he was infected with COVID-19 for the second time, exhibiting only symptoms of upper respiratory tract infection and no other discomfort. LESSONS: COVID-19 infection can lead to secondary myelitis and GBS, and GBS/ATM overlap syndrome is rare, but patients are significantly better after immunization and hormone therapy.

Source: Medicine

DOI: 10.1097/md.0000000000040346

Authors: Ruomeng Chen, Liang Wang, Binbin Wang, Xiujuan Song, Xiaoyun Liu

Institutions: Hebei Medical University, First Affiliated Hospital of Hebei Medical University, Second Hospital of Hebei Medical University

Language: English

Topic: Peripheral Neuropathies and Disorders

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,950