Work

Impact of the N-Heterocyclic Carbene (NHC) Ligand on the trans-[Pd(NHC)(NH2nBu)Cl2] Precatalyst Architecture in C–N Bond-Forming Reactions

Year: 2024

Type: article

Abstract: Two straightforward synthetic procedures leading to air- and moisture-stable trans -[Pd(NHC)(NH 2 n Bu)Cl 2 ] precatalysts are presented. These complexes, obtained by adding n -butylamine to [Pd(NHC)(μ-Cl)Cl] 2 or trans -[Pd(NHC)(DMS)Cl 2 ] precursors (DMS, dimethyl sulfide), demonstrate superior catalytic activity compared to their DMS counterparts in Buchwald–Hartwig amination reactions. Utilizing a more sustainable solvent (2-MeTHF), the catalyst loading was halved to 0.1 mol %, establishing this new system as a highly efficient and environmentally more friendly alternative to previous systems.

Source: Organometallics

DOI: 10.1021/acs.organomet.4c00419

Authors: Nestor Bracho Pozsoni, Fady Nahra, Kristof van Hecke, Catherine S. J. Cazin, Steven P. Nolan

Institutions: Ghent University, Flemish Institute for Technological Research

Language: English

Topic: N-Heterocyclic Carbenes in Organic and Inorganic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Fonds Wetenschappelijk Onderzoek, Universiteit Gent, Vlaamse regering