Work

Innv-01. Metastatic Glioblastoma to the Lung Treated With Lenvatinib

Year: 2024

Type: conference-abstract

Abstract: Glioblastoma is the most common malignant brain tumor. Despite its invasive nature, extra-cranial glioblastoma metastases are rare. We present a case of a 63 year-old woman with metastatic glioblastoma to the lung. Sarcomatous histology, a reported risk factor for disseminated disease, was found. Genomic alterations of TP53 mutation, TERT mutation, PTEN mutation, and +7/-10 were also uncovered. Early evidence suggests these molecular aberrations are common in metastatic glioblastoma. Treatment with third-line lenvatinib resulted in a mixed response. This case contributes to the growing body of evidence for the role of genomic alterations for predictive risk in metastatic glioblastoma. There remains an unmet need for treatment of metastatic glioblastoma.

Source: Neuro-Oncology

DOI: 10.1093/neuonc/noae165.0664

Authors: Carlen Yuen, Melike Pekmezci, Silin Bao, Xiao-Tang Kong

Institutions: University of California, Irvine, University of California, San Francisco, Community Regional Medical Center

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4404237465

Cites:

Cited by:

Related to: 10