Work

Rapid response of hand eczema with psoriasis overlap to upadacitinib

Year: 2024

Type: article

Abstract: Palmoplantar psoriasis is a clinical form of psoriasis that can represent a diagnostic challenge due to its clinical and histological similarity to hand eczema. The concomitant presentation of both pathologies is uncommon and has a limited response to common treatments. The four isoforms of Janus kinases (JAK) are crucial intracellular mediators associated with cytokine receptors. Upadacitinib has been approved for several diseases, including psoriatic arthritis and atopic dermatitis, and has demonstrated efficacy in psoriasis vulgaris as a secondary endpoint in patients with psoriatic arthritis. We present a case of overlapping psoriasis/chronic hand eczema that, after several therapeutic failures, obtained an excellent clinical response to upadacitinib.

Source: Revista Medicina Cutánea Ibero-Latino-Americana

DOI: 10.24875/mcute.m24000016

Authors: Luisa M. Guzmán-Pérez, Julia Montero-Menarguez, Christian Gutiérrez-Collar, Raquel Rivera-Díaz

Institution: Hospital Universitario 12 De Octubre

Language: English

Topic: Psoriasis: Treatment and Pathogenesis

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4404240446