Work

Benchmark of screening markers for KEAP1/NFE2L2 mutations and joint analysis with the K1N2-score

Year: 2024

Type: article

Abstract: Our recently published K1N2-score robustly predicts KEAP1/NFE2L2-mutations and pathway activation status, while its accessibility might be limited. We tested if the RNA expression data of six pathway-related genes and NQO1-IHC might be a reliable alternative using 348 KEAP1/NFE2L2 mutation-enriched NSCLC. While TXNRD1 RNA testing was the best-performing single-gene test, the combination of single-gene screening and validation with the K1N2-score achieved the highest performance when predicting mutation status or pathway activation.

Source: npj Precision Oncology

DOI: 10.1038/s41698-024-00744-1

Authors: Christoph Arolt, Andreas H. Scheel, Margaret Dugan, Robert Wild, Vanessa Richartz, Barbara Holz, Johannes Brägelmann, Svenja Wagener-Ryczek, Sabine Merkelbach-Bruse, Juergen Wolf, Reinhard Buettner, Luigi Catanzariti, Matthias Scheffler, Axel M. Hillmer

Institutions: University of Cologne, University Hospital Cologne

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,790

Funders: Deutsche Forschungsgemeinschaft, Deutsche Krebshilfe

Awards: G1191448895, SFB 1399: Mechanismen der MedikamentenEmpfindlichkeit und Resistenz beim kleinzelligen Bronchialkarzinom, G4888926582, Zellsortiersystem, Klärung der molekularen Ursachen der unterschiedlichen Behandlungserfolge beim ösophagealen Adenokarzinom

OpenAlex ID: W4404240789

FWCI: 0.259

Cites: 17

Cited by: 1

Related to: 10