Work

Splitting the chains: ultra-basal insulin analog uncovers a redox mechanism of hormone clearance

Year: 2024

Type: article

Abstract: Reporting in Nature Communications, Kjeldsen and colleagues describe a redox mechanism of insulin clearance based on separation of A- and B chains. Exploiting an ultra-long-acting analog protected from classical clearance pathways, the study highlights principles of protein stability in pharmacology.

Source: Nature Communications

DOI: 10.1038/s41467-024-54006-6

Author: Michael A. Weiss

Institutions: Indiana University Indianapolis, Indiana University School of Medicine

Language: English

Topic: Pancreatic function and diabetes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,790