Year: 2024
Type: article
Abstract: While links between certain chronotypes and poorer health outcomes have been well established in previous studies, few studies have examined the relationship between chronotype and cellular aging. Using data from the California Teachers Study (CTS), the present study evaluates the relationship between cellular aging and chronobiology through an analysis of leukocyte telomere length (LTL) and chronotype among 817 predominantly postmenopausal women with no history of cancer and occupations not associated with night-shift work. Unconditional logistic regression models were run to estimate odds ratios (ORs) for each chronotype category, adjusted for age, ethnicity, and smoking status. Analyses were then stratified by potential modifiers to assess whether results varied among specific subgroups within the sample. Women who reported being current evening types and evening types from teen years to now were significantly less likely to have short LTL compared to women who reported being current morning types or morning types from teen years to now (OR = 0.72; 95% CI = 0.53-0.98; OR = 0.57; 95% CI = 0.39-0.84). Our results suggest that women with no history of cancer who identify as evening chronotypes may undergo decreased cellular aging compared to women in the same population who identify as morning types. Further studies on populations of postmenopausal women are warranted.
Source: Chronobiology International
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funders: Public Health Institute, California Department of Public Health, University of California, University of Southern California, National Institutes of Health, Centers for Disease Control and Prevention, University of California, San Francisco, National Cancer Institute, National Institute of Environmental Health Sciences, National Center for Chronic Disease Prevention and Health Promotion, State of California
Awards: G105542917, G1134899476, G1288166743, G1352184354, G1365823874, G1395202410, G1606095464, G1666956106, G1722987392, G2337224928, G2395949410, G2612351997, G26190906, G3360784914, G3399131841, G3448447748, G3467199957, G3509688676, G3620431714, G3652486217, G3669704242, G3825486175, G3858317934, G3987779641, G4332884407, G4364285288, G4466429303, G4854421162, G4878091559, G504639888, G5463134625, G5601524489, G5778816553, Sleep and Cancer: Evaluation of Risk and Insights into Mechanisms, G609966341, G6452350125, G671936517, G6904952899, G6913321891, G6951404960, G6987947607, G7257662883, G7290139498, G7409959533, G757916477, G772794905, G7793014900, Specialized Cancer Center Support Grant, G8083727551, G8380263711, G8402570925, G8509442309, G9000011045, G9000021148, G9000079598, G9000091000, G9000092632, G9000325690, G9000328300, G946791773
OpenAlex ID: W4404246256