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Targeting RNA modifications in leukaemia: Epitranscriptomic drugs are the new kids on the block

Year: 2024

Type: article

Abstract: In this article, Chen et al. show that a chemical modification of transfer RNA, along its corresponding RNA modifier enzyme, is diminished in acute myeloid leukaemia. These findings further support the role of an aberrant epitranscriptome in haematological malignancies. Commentary on: Chen et al. Hydroxy-wybutosine tRNA modifications as indicators of disease progression and therapeutic targets in leukemia. Br J Haematol 2025; 206:517-530.

Source: British Journal of Haematology

DOI: 10.1111/bjh.19894

Author: Manel Esteller

Institutions: Institució Catalana de Recerca i Estudis Avançats, Josep Carreras Leukaemia Research Institute, Centro de Investigación Biomédica en Red de Cáncer, Universitat de Barcelona

Language: English

Topic: RNA modifications and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4404250712

FWCI:

Cites: 10

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Related to: 10