Work

Artificial Ex Utero Systems to Treat Severe Periviable Fetal Growth Restriction—A Possible Future Indication?

Year: 2024

Type: article

Abstract: Fetal growth restriction, or intrauterine growth restriction, is a common gestational condition characterized by reduced intrauterine growth. However, severe periviable fetal growth restriction is still associated with elevated perinatal mortality and morbidity. The current literature advises delivery once it is deemed that fetal compromise is evident. As uteroplacental insufficiency is the most common etiology of this condition, we hypothesize that the use of artificial ex utero systems to provide adequate nutrition and recreate the uterine environment may be a viable treatment option in this situation, even with the possibility of treating severe fetal growth restriction and prevent sequelae. There are promising experimental studies in sheep models investigating the artificial ex utero system for potential prenatal conditions, but future additional investigation is needed before translating to clinical trials in humans.

Source: Journal of Clinical Medicine

DOI: 10.3390/jcm13226789

Authors: Oluwateniayo O. Okpaise, Aaron J. Fils, Gabriele Tonni, Rodrigo Ruano

Institutions: Medway Maritime Hospital, University of Miami, Azienda Sanitaria Unità Locale di Reggio Emilia, Istituti di Ricovero e Cura a Carattere Scientifico

Language: English

Topic: Pregnancy and preeclampsia studies

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,955