Rethinking the connection between bipolar disorder and epilepsy from genetic perspectives
Year: 2024
Type: article
Study design: Observational Study
Abstract: Epilepsy and bipolar disorder (BD) exhibit considerable biochemical and genetic overlap. Our study unveiled a significant genetic correlation (rg = 0.154, P = 9.24 × 10–6) between BD-I and epilepsy, indicating a meaningful causal effect of epilepsy on BD-I (P = 0.0079, bxy = 0.1721, SE = 0.0648). Additionally, we identified 1.3k shared genetic variants and 6 significant loci, demonstrating substantial polygenic overlap. Notably, the rs9639379 variant within the SP4 gene exhibited strong associations with both BD-I and epilepsy, implicating SP4 in the etiology of both disorders.
Source: Genomic psychiatry :
DOI: 10.61373/gp024l.0061
Authors: Jin-Hua Huo, Ming Li
Institutions: Kunming Institute of Zoology, Chinese Academy of Sciences
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4404286074