Work

The association between trace amine-associated receptor 1 (TAAR1) genetic mutations and neuropsychiatric disorders

Year: 2024

Type: article

Abstract: Trace amine-associated receptor 1 (TAAR1) is an emerging drug target for the treatment of neuropsychiatric conditions. Several TAAR1-targeted therapeutics are currently in clinical and preclinical development. Emerging studies highlight links between TAAR1 single-nucleotide variants/polymorphisms and neuropsychiatric disorders. An improved understanding of TAAR1 genetic variants and their functional impact will inform the potential role of the TAAR1 system in the pathophysiology of neuropsychiatric conditions and for better therapeutic dosing. This viewpoint examines clinical and molecular studies involving TAAR1 genetic variants and their association with neuropsychiatric disorders.

Source: Genomic psychiatry :

DOI: 10.61373/gp024v.0058

Authors: Britto Shajan, Tarun Bastiampillai, Pramod C. Nair

Institutions: Flinders University, Monash University, South Australian Health and Medical Research Institute, The University of Adelaide

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4404286281

FWCI: 0.48

Cites: 30

Cited by: 3

Related to: 10