Work

The link between periodontitis and Alzheimer's disease – Brunei context

Year: 2024

Type: article

Abstract: The study aims to explore the relationship between periodontitis and Alzheimer's disease, focusing on the association and their potential impact on cognitive health. A retrospective study was conducted utilizing data obtained from the Brunei Health Information Management System (Bru-HIMS). The research study examined the correlation between periodontitis and Alzheimer's disease in individuals admitted to government healthcare settings between January 2014 and December 2023. Logistic regression and survival analysis were applied. After diagnosis of periodontitis, 81.6 %, 59.2 % and 40.8 % developed Alzheimer's disease after 1–3- and 5-years, respectively. Women (34.3 %) had significantly lower proportion of developing Alzheimer's disease after 5 years compared to men (46.3 %). Furthermore, those with history of tooth extraction has a high risk of developing Alzheimer's disease (Adjusted Hazard Ratio = 5.00; 95 % CI: 2.04, 12.28; p < 0.001). The study highlights the importance of understanding periodontal health in Alzheimer's patients and suggests further research and targeted interventions to mitigate its impact on cognitive function.

Source: Archives of Gerontology and Geriatrics Plus

DOI: 10.1016/j.aggp.2024.100097

Authors: Sarah Nabihah Mohamad Fadzli, Jagjit Singh Dhaliwal, Faiza Alam, Jacqueline Kamaluddin, Hanif Abdul Rahman

Institutions: Universiti Brunei Darussalam, Griffith University, Ministry of Health

Language: English

Topic: Oral microbiology and periodontitis research

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,100