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5'-Noraristeromycin Repurposing: Well-known S-Adenosyl-L-homocysteine Hydrolase Inhibitor As a Potential Drug Against Leukemia

Year: 2024

Type: article

Abstract: 5ˊ-Noraristeromycin as a racemic mixture of enantiomers was found to exhibit a pronounced cytotoxic effect on leukemia cells; IC50 for the Jurkat, K562, and THP-1 cell lines was 7.3, 1.3, and 3.7 μM, respectively. The general toxicity of 5'-noraristeromycin was studied in experiments on white mice upon single-dose intragastric administration; toxicometric parameters were determined, and the clinical and pathomorphological presentation of acute intoxication was studied. LD50 of the substance was shown to be 63.2 (52.7÷75.8) mg/kg; LD16, 44.7 mg/kg, and LD84, 89.4 mg/kg. Administration of the substance at a dose within the studied dose range is accompanied by systemic damage to the internal organs and tissues of the experimental animals.

Source: Acta Naturae

DOI: 10.32607/actanaturae.27443

Authors: O. N. Novikova, E. S. Matyugina, A. V. Gorshenin, Yu. I. Velikorodnaya, M. D. Krengauz, V. O. Vedernikova, P. V. Spirin, V. S. Prasolov, S. N. Kochetkov, A. L. Khandazhinskaya

Institutions: Federal Medical-Biological Agency, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow Institute of Physics and Technology

Language: English

Topic: Bioactive Compounds and Antitumor Agents

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4404297977

FWCI:

Cites: 20

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Related to: 10