Work

Modification by Lanthionine Synthetase AncKC in a Heterologous Escherichia coli System

Year: 2024

Type: article

Abstract: The increasing resistance of microorganisms to antibiotics makes it a necessity that we search for new antimicrobial agents. Due to their genetically encoded nature, peptides are promising candidates for new antimicrobial drugs. Lantipeptide andalusicin exhibits significant antimicrobial activity against Gram-positive bacteria, making it a promising scaffold for the development of DNA-encoded libraries of lantibiotics. In this study, the modification reaction of andalusicin by class III lanthionine synthetase AncKC was reconstructed in a heterologous Escherichia coli system. The results obtained open possibilities for creating novel peptide-based antimicrobial agents.

Source: Acta Naturae

DOI: 10.32607/actanaturae.27347

Authors: N. Z. Mirzoeva, S. O. Pipiya, Yu. A. Mokrushina, M. V. Serebryakova, A. A. Grigorieva, S. A. Dubiley, S. S. Terekhov, I. V. Smirnov

Institutions: Russian Academy of Sciences, Institute of Bioorganic Chemistry, Lomonosov Moscow State University, Skolkovo Institute of Science and Technology, Institute of Gene Biology

Language: English

Topic: Antimicrobial Peptides and Activities

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: diamond

OpenAlex ID: W4404298280

FWCI:

Cites: 8

Cited by:

Related to: 10