Work

Caspase-3 Activity and Autophagy Expression in the Development of Neuronal Resistance to Glutamate Toxicity

Year: 2024

Type: article

Abstract: Two periods of autophagy activation, differently significant for the development of resistance, were demonstrated in the model of neuronal resistance to the toxic effect of glutamate (deprivation of trophic factors). The autophagy inhibitor 3-methyladenine (3-MA) at a concentration of 1.25 mM significantly suppresses resistance development, but only if applied immediately after deprivation of trophic factors. Inhibition of autophagy with 3-MA immediately during deprivation does not affect resistance production. In addition, activation of autophagy is responsible for the decrease in caspase-3 activity, although the mechanism of this process remains unclear. We hypothesize that resistance production in neurons is mediated by a decrease in caspase-3 activity as a result of autophagy activation.

Source: Нейрохимия

DOI: 10.31857/s1027813324020041

Authors: O. P. Aleksandrova, D. V. Kuznetsova, A. A. Lyzhin, L. G. Khaspekov, N. V. Gulyaeva, A. A. Yakovlev

Institutions: Russian Academy of Sciences, Institute of Higher Nervous Activity and Neurophysiology, Research Center of Neurology, Sechenov University, Moscow Research and Clinical Center for Neuropsychiatry

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4404311841

FWCI:

Cites: 12

Cited by:

Related to: 10