Work

Lost in translation: Illuminating protein mislocalization through high-content screening microscopy

Year: 2024

Type: article

Abstract: Establishing the subcellular distribution of all proteins encoded by the human genome remains a key objective of life science research. This is particularly important in the context of proteins that, through genetic sequencing of patients, have been identified as containing missense mutations. A recent publication in Cell 1 highlights the prominence of protein mislocalization as a hallmark of dysfunctional proteins. The use of high-content subcellular phenotypic screens and allied technology by Lacoste and colleagues has enormous potential to change the landscape of how we approach both diagnostic and therapeutic decisions.

Source: Cell Genomics

DOI: 10.1016/j.xgen.2024.100695

Authors: Lucy G. Dornan, Jeremy C. Simpson

Institution: University College Dublin

Language: English

Topic: Genomics and Rare Diseases

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $8,900