Year: 2024
Type: article
Abstract: We report a method to furnish substituted 1H‐indazoles via a coupling of 3‐acetyl substituted nitroarenes and arylhydrazines. Reactions progressed in the presence of cobalt(II) acetylacetonate catalyst, TEMPO oxidant, and Cs2CO3 base. Functional groups including bromo, chloro, nitro, and trifluoromethoxy groups were compatible with reaction conditions. The proposed mechanism was based on a nucleophilic substitution of hydrogen para to nitro group. Our method feature a convenient pathway to directly obtain substituted 1H‐indazoles which avoid the use of pre‐functionalized starting materials. Indazole could play a role as the directing group for a palladium‐catalyzed C(sp2)─H arylation with iodobenzene.
Source: ChemistrySelect
Authors: Duyen K. Nguyen, Giang T. H. Tran, Tung T. Nguyen
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Award: G1332829485
OpenAlex ID: W4404320801