Anticancer potential of copper( i ) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands

Year: 2024

Type: article

Abstract: (3) a significant antitumor activity in 3D spheroidal models of human colon cancer cells. Investigations focused on the mechanism of action evidenced protein disulfide-isomerase (PDI) as an innovative molecular target for this class of phosphane copper(i) complexes. By hampering PDI activity, copper(i) complexes were able to cause an imbalance in cancer cell redox homeostasis thus leading to cancer cell death - a non-apoptotic programmed cell death.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d4md00610k

Authors: Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina Marzano

Institutions: Università di Camerino, Roma Tre University, University of Padua

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Università degli Studi Roma Tre, European Commission, Ministero dell’Istruzione, dell’Università e della Ricerca, Università degli Studi di Padova, Università degli Studi di Camerino

OpenAlex ID: W4404325831