Work

Paired Electro‐Synthesis of Remote Amino Alcohols with/in H 2 O

Year: 2024

Type: article

Abstract: Amino alcohols, particularly remote amino alcohols and peptide alcohols, are valuable due to their functional diversity in biologically active compounds. However, traditional synthesis methods face significant challenges, making electrochemistry an attractive alternative. We have developed a mild and biocompatible sequential paired electrolysis strategy, leveraging copper‐electrocatalysis to synthesize diverse remote amino alcohols, including unnatural peptide alcohols. Both experimental results and density functional theory (DFT) calculations demonstrated that water serves as both the hydroxyl source and the solvent, facilitating the generation of CuH with Cu(I) at the cathode, which in turn reduces the aldehyde intermediates formed during the reaction.

Source: Angewandte Chemie

DOI: 10.1002/ange.202418277

Authors: Xinyue Fang, Xinwei Hu, Quan‐Xin Li, Shao‐Fei Ni, Zhixiong Ruan

Institutions: State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Shantou University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Guangzhou Medical University, National Natural Science Foundation of China, Guangzhou Municipal Science and Technology Project, Basic and Applied Basic Research Foundation of Guangdong Province