Year: 2024
Type: article
Abstract: A catalytic protocol for the enantioselective hydrogenation and transfer hydrogenation of α-nitro ketones was developed, providing a wide range of β-nitro-α-phenylethanols with high yields and excellent enantioselectivities (up to 98% yield and up to >99.9% ee). Compatibility with a wide range of solvents and bases demonstrates the robustness of this reaction. The synthetic potential of the protocol was demonstrated by the high TON experiment as well as the application in the synthesis of key intermediates of mirabegron (S/C = 10,000, 95% yield, 99% ee).
Source: Organic Letters
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Funders: National Natural Science Foundation of China, Science, Technology and Innovation Commission of Shenzhen Municipality, Southern University of Science and Technology, Shenzhen Municipal Science and Technology Innovation Council, National Key Research and Development Program of China, Basic and Applied Basic Research Foundation of Guangdong Province
OpenAlex ID: W4404326735