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Eradication of Pseudomonas aeruginosa Persister Cells by Eravacycline

Year: 2024
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Pseudomonas aeruginosa is a leading bacterial pathogen that causes persistent infections. One major reason that antibiotics fail to clear such infections is the presence of a dormant subpopulation called persister cells. To eradicate persister cells, it is important to change drug development from traditional strategies that focus on growth inhibition to the search for new leads that can kill dormant cells. In this study, we demonstrate that eravacycline can effectively accumulate in P. aeruginosa persister cells, leading to strong killing during wakeup, including persister cells in both planktonic cultures and biofilms of the wild-type strain and its mucoid mutant. The effects of eravacycline on persister control were further validated in vivo using a lung infection model in mice. Collectively, these results demonstrate the possibility to control persister cells of bacterial pathogens by targeting dormancy.
DOI: 10.1021/acsinfecdis.4c00349
Authors: Sweta Roy, Zeynep S. Cakmak, Salma Mahmoud, Mahsa Sadeghzadeh, Guirong Wang, Dacheng Ren
Language: English
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: Edna Bailey Sussman Foundation, State University of New York, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institute of Biomedical Imaging and Bioengineering, European Social Fund
Awards: G1346054178, Roles of human surfactant collectin variants in the susceptibility of COVID-19, G274188747, G2745523575, G9000080977, G9000121942, Optogenetic Control of Bacterial Persistence to Study Biomaterial Infections
OpenAlex ID: W4404328405
FWCI: 1.04
Cites: 49
Cited by: 9
Related to: 10