Work

Angioedema following venipuncture in a patient on angiotensin‐converting enzyme inhibitor and dipeptidyl peptidase‐IV inhibitor therapy: A case report

Year: 2024

Type: article

Abstract: Acquired angioedema (AAE) is a rare, potentially life‐threatening condition, primarily induced by medications, with attacks typically triggered by major trauma. We report a rare case of AAE triggered locally by minor trauma—a forearm venipuncture—in a 77‐year‐old male taking ramipril and sitagliptin. The venipuncture and these medications acted synergistically through distinct pathways in bradykinin metabolism, resulting in localized AAE. This case highlights the importance of recognizing minor trauma as a potential trigger in patients on multiple AAE‐inducing medications.

Source: JEADV Clinical Practice

DOI: 10.1002/jvc2.582

Authors: Adrien Bénic, Adrien Boyard, Alexan Pogossian, Laurent Misery, Anne‐Marie Roguedas‐Contios

Institutions: Centre Hospitalier Régional Universitaire de Brest, Université de Bretagne Occidentale

Language: English

Topic: Coagulation, Bradykinin, Polyphosphates, and Angioedema

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,700