Nanotherapeutic Approaches of Interleukin‐3 to Clear the α‐Synuclein Pathology in Mouse Models of Parkinson's Disease (Adv. Sci. 42/2024)
Year: 2024
Type: article
Abstract: Parkinson's Disease IL-3 is a promising therapeutic target in neurodegenerative diseases. Breaking through its limitation of crossing blood-brain barrier, the article number 2405364 by Ruijing Liang, Yunlong Zhang, and co-workers reveals a novel nanogel delivery technology for IL-3 (termed RVG-IL3 NGs). RVG-IL3 NGs can be taken up by dopaminergic neurons and microglia in the brain (as seen in the cloud), releasing IL-3 (indicated by the arrow) and clearing -synuclein pathology in these two neural cells (indicated by the two corresponding eagles), thereby improving the phenotype of Parkinson's disease. This study builds a new route for cytokine-based intervention in treating neurodegenerative diseases.
Source: Advanced Science
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $6,120
OpenAlex ID: W4404332549