Work

Integrating continuous flow reaction and work-up: chiral amine resolution, separation and purification using a novel coalescing filter system

Year: 2024

Type: article

Abstract: )-1-phenylethylamine in 43% yield and >99% ee from racemate. The work illustrates how typical reactions, work-up and purification steps that involve multiple phases can be telescoped together using both new and commercially available laboratory equipment. This continuous system uses mild reaction conditions, green solvents and minimises their use for reduced waste.

Source: Reaction Chemistry & Engineering

DOI: 10.1039/d4re00442f

Authors: Bethan M. Rowley, Lisa A. Thompson, Luke A. Power, James Daglish, Emma Parks, James Birbeck, Steve Marsden, Nikil Kapur, A. John Blacker

Institutions: University of Leeds, Croda (United Kingdom)

Language: English

Topic: Innovative Microfluidic and Catalytic Techniques Innovation

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: hybrid

Funders: AstraZeneca, Engineering and Physical Sciences Research Council, Biotechnology and Biological Sciences Research Council

Awards: G123386196, Industrial CASE Account - University of Leeds 2018, G3680636218, Continuous Separation Of Biotansformation Products, G6753712289

OpenAlex ID: W4404332588

FWCI: 0.21

Cites: 38

Cited by: 2

Related to: 10