Work

Functional connectotomy of a whole-brain model reveals tumor-induced alterations to neuronal dynamics in glioma patients

Year: 2024

Type: article

Abstract: Brain tumors can induce pathological changes in neuronal dynamics that are reflected in functional connectivity measures. Here, we use a whole-brain modeling approach to investigate pathological alterations to neuronal activity in glioma patients. By fitting a Hopf whole-brain model to empirical functional connectivity, we investigate glioma-induced changes in optimal model parameters. We observe considerable differences in neuronal dynamics between glioma patients and healthy controls, both on an individual and population-based level. In particular, model parameter estimation suggests that local tumor pathology causes changes in brain dynamics by increasing the influence of interregional interactions on global neuronal activity. Our approach demonstrates that whole-brain models provide valuable insights for understanding glioma-associated alterations in functional connectivity.

Source: Network Neuroscience

DOI: 10.1162/netn_a_00426

Authors: Christoffer G. Alexandersen, Linda Douw, Mona L. M. Zimmermann, Christian Bick, Alain Goriely

Institutions: University of Oxford, Amsterdam Neuroscience, Amsterdam University Medical Centers, Cancer Center Amsterdam, Vrije Universiteit Amsterdam

Language: English

Topic: Functional Brain Connectivity Studies

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,750