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Synthesis and biological activity of substituted 5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamides

Year: 2024

Type: article

Abstract: A four-component solvent-free reaction of acetoacetic acid amide with dimedone, aromatic aldehydes and ammonium acetate leads to new substituted 5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamides. The structures of the products were proved using IR, 1H and 13C NMR spectroscopy, mass spectrometry and X-ray diffraction analysis. The synthesized compounds were tested for antimicrobial and antinociceptive activities.

Source: Журнал Общей Химии

DOI: 10.31857/s0044460x24050032

Authors: N. V. Nosova, М. О. Starovoytova, R. R. Mahmudov, V. V. Novikova, М. V. Dmitriev, V. L. Gein

Institutions: Ministry of Health of the Russian Federation, Perm State Pharmaceutical Academy, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W4404337348

FWCI:

Cites: 14

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Related to: 10